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  • anna 2022

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19F NMR studies relying on the use of fluorinated nucleotides make an important contribution to our understanding of the structure and function of nucleic acids. By first synthesizing 4'-SCF3-thymidine (T4'-SCF3) and incorporating it into various oligonucleotides by solid-phase synthesis, we demonstrated that the 4'-SCF3 group has a flexible orientation in the minor groove of DNA duplexes and also fits well in the context of various higher-order DNA structures. The magnetically equivalent fluorine atoms in 4'-SCF3 DNA constitute an isolated spin system that provides high 19F NMR sensitivity. This novel approach also provides excellent resolution of the positioning of T4'-SCF3 within different DNA structures. The high structural adaptability and high sensitivity of T4'-SCF3 provide a valuable 19F NMR probe for quantitatively distinguishing different DNA structures with single nucleotide resolution and for monitoring the dynamics of interactions in the minor groove of double-stranded DNA.

marko angewandte 2022

Link to the article accepted for publication in Angew. Chem. is available here

28. 9. 2022

The Slovenian NMR Centre is proud to be a member of the R-NMR project, which is a coordination and support action (CSA) of the Horizon Europe framework program. The R-NMR project includes more than 25 European NMR facilities and its main purpose is to provide users with the ability to perform remote measurements with an experience comparable to on-site access to all major NMR sites in Europe. Activities will include training of spectroscopists in the remote use of spectrometers as well as data processing, storage and safe access to experimental data.
Remote/digital access will significantly strengthen the resilience of the infrastructures under adverse conditions such as restrictions of travel, new pandemic waves, temporary lockdown conditions, etc. Furthermore, a reduction in user travel it will also reduce the carbon footprint of access to infrastructure and significantly improve the resilience of research infrastructures to future changes.

R-NMR project

R-NMR website: Link

16. 9. 2022

Vesna Štih was awarded a poster award at the XXIV International RoundTable on Nucleosides, Nucleotides and Nucleic Acids conference that took place at the Karolinska institute in Stockholm between August 28 and 31, 2022. Award holds the name of eminent scientist Professor Anthony Holy.

vesna irt poster award

Congratulations 🥳 🎉

2. 9. 2022