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Slovenian NMR Centre
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A New Pathway of DNA G-Quadruplex Formation.
Hot paper and the front cover of Angew. Chem. Int. Ed., May 5, 2014

Guanine-rich DNA sequences can self-assemble into specific pre-organized DNA structures, where two by two guanine residues shown as 'Duets' are involved in GG N1-carbonyl symmetric base pairs. In our Communication we demonstrate the transition of these 'Duets' into guanine-quartets, presented as a 'String Quartet' when interacting with cations such as potassium ions. This rearrangement consequently leads to formation of G-quadruplex structures.


More information and article are available here.

14. 5. 2014