peter podbevsek

Peter Podbevšek

Ph.D.

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peter.podbevsek@ki.si

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(01) 47-60-240

Peter Podbevšek was born on November 16, 1981 in Slovenj Gradec, Slovenia. While studying cation binding within G-quadruplex structures in 2009 he received his B.Sc. degree in biochemistry at the Faculty of chemistry and chemical technology, University of Ljubljana. He spent 4 months as a Marie Curie fellow at the University of southern Denmark, Odense working with short RNA hairpins. Afterwards he was involved in the “Young researcher” program at the NMR Center at the National institute of chemistry in Ljubljana under the supervision of Prof. Janez Plavec. In the year 2011 he was awarded his Ph.D. degree in biochemistry and molecular biology at the Faculty of Medicine, University of Ljubljana. His Ph.D. work was focused on the influence of chemical modifications and cations on 3D structures of oligonucleotides. As a postdoc he spent two years at the International School for Advances Studies, SISSA in Trieste, Italy. His postdoc project supervised by Prof. Stefano Gustincich was structural characterization of long noncoding RNAs. Dr. Podbevšek is a coauthor of 10 research papers. He is involved in the training of undergraduate students and organizes scientific meetings.

Research interests:
• Structure and dynamics of G-quadruplexes originating from promoter sequences
• The influence of oxidative and nitrative stress on DNA structures
• Structure-function relationship of non-coding RNAs

SELECTED PUBLICATIONS

1

P. Podbevsek and J. Plavec
KRAS promoter oligonucleotide with decoy activity dimerizes into a unique topology consisting of two G-quadruplex units
Nucleic Acids Res. 2016, 44(2), 917-925.
Web access at Oxford Journals.

2

P. Podbevsek, C.R. Allerson, B. Balkrishen and J. Plavec
Solution-state structure of a fully alternately 2'-F/2'-OMe modified 42-nt dimeric siRNA construct
Nucleic Acids Res., 2010, 38 (20), 7298-7307.
Web access at Oxford Journals

3

P. Podbevsek, P. Sket and J. Plavec
Stacking and Not Solely Topology of T3 Loops Controls Rigidity and Ammonium Ion Movement within d(G4T3G4)2 G-Quadruplex
J. Am. Chem. Soc. 2008, 130 (43), 14287-14293.

LIST OF PUBLICATIONS

2018

13

S. Takahashi, K. T. Kim, P. Podbevsek, J. Plavec, B. H. Kim and N. Sugimoto
Recovery of the formation and function of oxidized G-quadruplexes by pyrene-modified guanine-tract
J. Am. Chem Soc. 2018, 140 (17), 5774-5783.
Web access at ACS Publications

12

P. Podbevsek, F. Fasolo, C. Bon, L. Cimatti, S. Reisser, P. Carninci, G. Bussi, S. Zucchelli, J. Plavec and S. Gustincich
Structural determinants of the SINEB2 element embedded in the long non-coding RNA activator of translation AS Uchl1
Sci. Rep. 2018, 8, article number: 3189.
Web access at nature.com

2017

11

H. Tateishi-Karimata, T. Ohyama, T. Muraoka, P. Podbevsek, A. M. Wawro, S. Tanaka, S. Nakano, K, Kinbara, J. Plavec and N. Sugimoto
Newly characterized interaction stabilizes DNA structure: oligoethylene glycols stabilize G-quadruplexes CH–π interactions
Nucleic Acids Res. 2017, 45(12), 7021-7030.
Web access at Oxford Journals

10

T. Fujii, P. Podbevsek, J. Plavec and N. Sugimoto
Effects of metal ions and molecular crowding on G-quadruplex topology
J. Inorg. Biochem., 2017, 166, 190-198.
Web access at ScienceDirect

2016

9

P. Podbevsek and J. Plavec
KRAS promoter oligonucleotide with decoy activity dimerizes into a unique topology consisting of two G-quadruplex units
Nucleic Acids Res. 2016, 44(2), 917-925.
Web access at Oxford Journals.

2014

8

S. Medic, P. Podbevsek and J. Plavec
Solution Structure of a Prion Protein Aptamer Analogue
Croat. Chem. Acta 2014, 87 (4), 321–325.
Web access at CCA

2013

7

S. P. Sau, A. S. Madsen, P. Podbevsek, N. K. Andersen, T. S. Kumar, S. Andersen, R. L. Rathje, B. A. Anderson, D. C. Guenther, S. Karmakar, P. Kumar, J. Plavec, J. Wengel and P. J. Hrdlicka
Identification and Characterization of Second-Generation Invader Locked Nucleic Acids (LNAs) for Mixed-Sequence Recognition of Double-Stranded DNA
J. Org. Chem. 2013, 78 (19), 9560-9570.
Web access at ACS publications

6

J. Stanek, P. Podbevsek, W. Kozminski, J. Plavec and M. Cevec
4D Non-uniformly sampled C,C-NOESY experiment for sequential assignment of 13C,15N-labeled RNAs
J. Biomol. NMR 2013, 57 (1), 1-9.
Web access at Spriger

2011

5

J. Zavasnik, P. Podbevsek and J. Plavec
Observation of water molecules within the bimolecular d(G3CT4G3C)2 G-quadruplex
Biochemistry 2011, 50 (19), 4155-4161.
Web access at ACS Publications

2010

4

P. Podbevsek, C.R. Allerson, B. Balkrishen and J. Plavec
Solution-state structure of a fully alternately 2'-F/2'-OMe modified 42-nt dimeric siRNA construct
Nucleic Acids Res., 2010, 38 (20), 7298-7307.
Web access at Oxford Journals

2008

3

P. Podbevsek, P. Sket and J. Plavec
Stacking and Not Solely Topology of T3 Loops Controls Rigidity and Ammonium Ion Movement within d(G4T3G4)2 G-Quadruplex
J. Am. Chem. Soc. 2008, 130 (43), 14287-14293.

2007

2

P. Podbevsek, P. Sket and J. Plavec
NMR study of ammonium ion binding to d[G3T4G4]2 and d[G4(T4G4)3] G-quadruplexes
Nucl. Nucl. and Nucl. Acids 2007, 26 (10), 1547-1551.

1

P. Podbevsek, N. V. Hud and J. Plavec
NMR Evaluation of Ammonium Ion Movement within a Unimolecular G-quadruplex in Solution
Nucleic Acids Res. 2007, 35 (8), 2554-2563.