Maja Marušič
Ph.D.
marusic.maja@ki.si
+386 1 4760 227
Maja Marušič was born on 19th of May, 1987 , in Novo Mesto, Slovenia. She received her B.Sc. in biochemistry at Faculty of Chemistry and Chemical Technology, University of Ljubljana, Slovenia, in 2011. From 2011-2017 she was working as Young researcher under supervision of Prof. Dr. Janez Plavec at Slovenian NMR Centre, National Institute of Chemistry, Ljubljana, Slovenia, exploring characteristics of non-canonical DNA structures with NMR, CD and UV spectroscopy and molecular dynamics. In 2017 she defended her Ph.D. thesis with the title "Guanine rich sequences of human papillomaviruses genomes and their secondary structures" at Faculty of Medicine, University of Ljubljana, Slovenia. For her Ph.D. thesis she received National Loreal-UNESCO scholarship "For women in science" and Great Krka prize in 2017. In 2017 she joined Prof. Dr. Katja Petzold lab at Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden, as postdoc researcher, focusing on dynamics of ribosomal RNA. In 2020 she returned to Slovenian NMR centre, where she is employing various isotope labelling techniques for production of DNA to measure dynamics of non-canonical G-rich structure by relaxation dispersion NMR.
Research interests:
• NMR spectroscopy of nucleic acids
• structure, dynamics and interactions of nucleic acids
• folding and sequence-structure relationship of non-canonical G-rich nucleic acids
SELECTED PUBLICATIONS
1
M. Marusic, L. Hosnjak, P. Krafcikova, M. Poljak, V. Viglasky and J. Plavec
The Effect of Single Nucleotide Polymorphisms in G-rich Regions of High-Risk Human Papillomaviruses on Structural Diversity of DNA
Biochim. Biophys. Acta 2017, 1861, 1229-1236.
Web access at ScienceDirect
2
M. Marusic and J. Plavec
The Effect of DNA Sequence Directionality on G-Quadruplex Folding
Angew. Chem. Int. Ed. 2015, 54(40), 11716-11719.
Web access at Wiley Online Library
3
M. Marusic, R. N. Veedu, J. Wengel and J. Plavec
G-rich VEGF aptamer with locked and unlocked nucleic acid modifications exhibits a unique G-quadruplex fold
Nucleic Acids Res. 2013, 41(29), 9524-9536.
Web access at Oxford Journals
LIST OF PUBLICATIONS
2023
16
M. Marušič, M. Toplishek and J. Plavec
NMR of RNA - Structure and interactions
Curr. Opin. Struct. Biol. 2023, 79, 102532.
Web access at Science Direct
2022
15
E. Ruggiero, E. Lavezzo, M. Grazioli, I. Zanin, M. Marušič, J. Plavec, S. N. Richter and S. Toppo
Human Virus Genomes Are Enriched in Conserved Adenine/Thymine/Uracil Multiple Tracts That Pause Polymerase Progression
Front. Microbiol. 2022, 13, article number: 915069.
Web access at frontiers in Microbiology
14
E. Ruggiero, I. Frasson, E. Tosoni, M. Scalabrin, R. Perrone, M. Marušič, J. Plavec and S. N. Richter
Fused in Liposarcoma (FUS) protein, a New Player in the Regulation of HIV-1 Transcription, binds to Known and Newly identified LTR G-quadruplexes
ACS Infect. Dis. 2022, 8 (5), 958-968.
Web access at ACS Publications
2021
13
S. Lago, M. Nadai, E. Ruggiero, M. Tassinari, M. Marušič, B. Tosoni, I. Frasson, F. M. Cernilogar, V. Pirota, F. Doria, J. Plavec, G. Schotta and Sara N. Richter
The MDM2 inducible promoter folds into four-tetrad antiparallel G-quadruplexes targetable to fight malignant liposarcoma
Nucleic Acids Res. 2021, 49 (2), 847-863.
Web access at Oxford Journals
2019
12
M. Marušič, J. Schlagnitweit, K. Petzold
RNA dynamics by NMR spectroscopy
ChemBioChem. 2019, 20(21), 2685-2710.
Web access at Wiley Online Library
11
M. Marusic and J. Plavec
Towards Understanding polymorphism of G-rich region of human papillomavirus type 52 by NMR
Molecules 2019, 24 (7): 1294.
Web access at MDPI
2018
10
L. Baronti, H. Karlsson, M. Marušič, K. Petzold
A guide to large-scale RNA sample preparation
Anal. Bioanal. Chem. 2018, 410 (14), 3239-3252
Web access at Springer
9
S. Bozic Abram, M. Marusic, M. Lenarcic Zivkovic, J. Brcic and J. Plavec
Non-canonical structures in promoter modulate gene expression in Escherichia coli
Croat. Chem. Acta 2018, 91(2), 163-170.
Web access at CCA
2017
8
M. Marusic, L. Hosnjak, P. Krafcikova, M. Poljak, V. Viglasky and J. Plavec
The Effect of Single Nucleotide Polymorphisms in G-rich Regions of High-Risk Human Papillomaviruses on Structural Diversity of DNA
Biochim. Biophys. Acta 2017, 1861, 1229-1236.
Web access at ScienceDirect
2015
7
M. Marusic and J. Plavec
The Effect of DNA Sequence Directionality on G-Quadruplex Folding
Angew. Chem. Int. Ed. 2015, 54(40), 11716-11719.
Web access at Wiley Online Library
6
M. Marusic, H. Tateishi-Karimata, N. Sugimoto and J. Plavec
Structural foundation for DNA behavior in hydrated ionic liquid: An NMR study
Biochimie 2015, 108, 169-177.
Web access atScienceDirect
5
S.L. Edwards, V. Poongavanam, J. R. Kanwar, K. Roy, K. M. Hillman, N. Prasad, R. Leth-Larsen, M. Petersen, M. Marusic, J. Plavec, J. Wengel and R. N. Veedu
Targeting VEGF with LNA-Stabilized G-rich Oligonucleotide for Efficient Breast Cancer Inhibition
Chem Commun. 2015, 51 (46), 9499-9502.
Web access at RSC Publishing
2013
4
S. Azizoğlu, R. Kizilel,M. Marušič, I. H. Kavakli, B. Erman, S. Kizilel
Computational and experimental investigation of DNA repair protein photolyase interactions with low molecular weight drugs.
J. Mol. Recognit. 2013, 26 (7), 297-307.
Web access at Wiley Online Library.
3
M. Marusic, R. N. Veedu, J. Wengel and J. Plavec
G-rich VEGF aptamer with locked and unlocked nucleic acid modifications exhibits a unique G-quadruplex fold
Nucleic Acids Res. 2013, 41(29), 9524-9536.
Web access at Oxford Journals
2
K. Tluckova, M. Marusic, P. Tothova, L. Bauer, P. Sket, J. Plavec and V. Viglasky
Human Papillomavirus G-Quadruplexes
Biochemistry 2013, 52 (41), 7207-7216.
Web access at ACS publications
2012
1
M. Marušič, P. Šket, L. Bauer, V. Viglasky, and J. Plavec
Solution-state structure of an intramolecular G-quadruplex with propeller, diagonal and edgewise loops
Nucleic Acids Res. 2012, 40 (14), 6946-6956.
Web access at Oxford Journals