janez_plavec

Gregor Ilc

Ph.D.

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gregor.ilc@ki.si

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(01) 47-60-311

Gregor Ilc (M) was born on 2nd August 1980 in Celje, Slovenia. In 2004, at the Faculty of Chemistry and Chemical Technology, University of Ljubljana, he acquired Bachelor in biochemistry entitled "The impact of modifications on the guanine ring to the formation of G-quadruplexes." From 2007 to 2015 he conducted doctoral studies as a researcher at the National Center for high resolution NMR spectroscopy at the Chemistry Institute under the mentorship of Prof. Janez Plavec. In 2016 he received the title of Doctor of Philosophy for his doctoral thesis entitled “NMR Structural Studies of Human Prion Protein Mutants", at the University of Ljubljana. He is involved in the optimization of NMR spectrometers and their use, and in 2006 he received from the manufacturer of NMR spectrometer Varian Inc., a certificate for technical assistance in the field of NMR spectroscopy. Scientifically he has participated in the various techniques of NMR spectroscopy. Among these techniques we include development of pulse sequences and their use for determining the structures of protein molecules. His scientific research has shown that a strong correlation exist between the primary sequence of the prion protein and secondary structural elements. His studies on prion proteins containing naturally occurring mutations gave a clue on early events of human genetic prion diseases. In 2011, at the International Conference MMCE he was award for a poster. Dr. Ilc is co-author of 9 publications that have been published in scientific journals with international peer-review system. He also participated in the organization of several scientific meetings.

Research interests of G. Ilc include studies of intrinsically disordered proteins and cellular signaling, mechanisms of nucleic acid recognition by DNA binding proteins, mechanisms of protein folding and misfolding and protein dynamics.

SELECTED PUBLICATIONS

1

I. Biljan, G. Ilc, G. Giachin, A. Raspadori, I. Zhukov, J. Plavec and G. Legname
Toward the molecular basis of inherited prion diseases: NMR structure of the human prion protein with V210I mutation
J. Mol. Biol. 2011, 412 (4), 660–673.
Web access at ScienceDirect

2

I. Biljan, G. Ilc, G. Giachin, J. Plavec and G. Legname
Structural Rearrangements at Physiological pH: NMR insights from the V210I Human Prion Protein Mutant
Biochemistry 2012, 51 (38), 7465-7474.
Web access at ACS publications

3

I. Biljan, G. Ilc, G. Giachin, J. Plavec and G. Legname
Structural Rearrangements at Physiological pH: NMR insights from the V210I Human Prion Protein Mutant
Biochemistry 2012, 51 (38), 7465-7474.
Web access at ACS publications

4

I. Biljan, G. Ilc, G. Giachin, G. Legname and J. Plavec
NMR Structural Studies of Human Cellular Prion Proteins
Curr. Top. Med. Chem. 2013, 13(19), 2407-2418.
Web access at Bentham Science

5

G. Giachin, I. Biljan, G. Ilc, J. Plavec and G. Legname
Probing Early Misfolding Events in Prion Protein Mutants by NMR Spectroscopy
Molecules 2013, 18 (8), 9451-9476.
Web access at MDPI

6

M. Pavsic, G. Ilc, T. Vidmar, J,. Plavec and B. Lenarcic
The cytosolic tail of the tumor marker protein Trop2 – a structural switch triggered by phosphorylation
Sci. Rep. 2015, 5, article number: 10324.
Web access at nature.com

LIST OF PUBLICATIONS

2018

14

M. Kozorog, M.-A. Sani, M. Lenarcic Zivkovic, G. Ilc, V. Hodnik, F. Separovic, J. Plavec and G. Anderluh
19F NMR studies provide insights into lipid membrane interactions of listeriolysin O, a pore forming toxin from Listeria monocytogenes
Sci. Rep. 2018, 8, article number: 6894.
Web access at nature.com

2017

13

V. Kovač, B. Zupancic, G. Ilc, J. Plavec and V. Curin Serbec
Truncated prion protein PrP226* - A structural view on its role in amyloid disease
Biochem. Biophys. Res. Commun. 2017, 484 (1), 45-50.
Web access at ScienceDirect

2016

12

U. Slapsak, G. Salzano, L. Amin, R.N.N. Abskharon, G. Ilc, B. Zupancic, I. Biljan, J. Plavec, G. Giachin and G. Legname
The N terminus of the Prion Protein Mediates Functional Interactions with the Neuronal Cell Adhesion Molecule (NCAM) Fibronectin Domain
J. Biol. Chem. 2016, 291 (42), 21857-21868.
Web access at ASBMB

11

B. Japelj, G. Ilc, J. Marusic, J. Sencar, D. Kuzman and J. Plavec
Biosimilar structural comparability assessment by NMR: from small proteins to monoclonal antibodies
Sci. Rep. 2016, 6, article number: 32201.
Web access at nature.com

10

S. Drmota Prebil, U. Slapsak, M. Pavsic, G. Ilc, V. Puz, E. de Almeida Ribeiro, D. Anrather, M. Hartl, L. Backman, J. Plavec, B. Lenarčič and K. Djinovic-Carugo
Structure and calcium-binding studies of calmodulin-like domain of human non-muscle α-actinin-1
Sci. Rep. 2016, 6, article number: 27383.
Web access at nature.com

2015

9

M. Pavsic, G. Ilc, T. Vidmar, J,. Plavec and B. Lenarcic
The cytosolic tail of the tumor marker protein Trop2 – a structural switch triggered by phosphorylation
Sci. Rep. 2015, 5, article number: 10324.
Web access at nature.com

2013

8

T. Ilc, P. Sket, J. Plavec, M. Webba da Silva, I. Drevensek Olenik, L. Spindler
Formation of G-wires : the role of G:C-base pairing and G-quartet stacking
J. Phys. Chem. C, Nanomaterials and interfaces, 2013, 117 (44), 23208-23215.
Web access at ACS publications

7

I. Biljan, G. Ilc, G. Giachin, G. Legname and J. Plavec
NMR Structural Studies of Human Cellular Prion Proteins
Curr. Top. Med. Chem. 2013, 13(19), 2407-2418.
Web access at Bentham Science

6

G. Giachin, I. Biljan, G. Ilc, J. Plavec and G. Legname
Probing Early Misfolding Events in Prion Protein Mutants by NMR Spectroscopy
Molecules 2013, 18 (8), 9451-9476.
Web access at MDPI

2012

5

I. Biljan, G. Ilc, G. Giachin, J. Plavec and G. Legname
Structural Rearrangements at Physiological pH: NMR insights from the V210I Human Prion Protein Mutant
Biochemistry 2012, 51 (38), 7465-7474.
Web access at ACS publications

4

I. Biljan, G.Giachin, G.r Ilc, I. Zhukov, J. Plavec and G. Legname
Structural basis for the protective effect of the human prion protein carrying the dominant-negative E219K polymorphism
Biochem. J. 2012, 446, 243-251.
Web access at Biochemical Journal

2011

3

I. Biljan, G. Ilc, G. Giachin, A. Raspadori, I. Zhukov, J. Plavec and G. Legname
Toward the molecular basis of inherited prion diseases: NMR structure of the human prion protein with V210I mutation
J. Mol. Biol. 2011, 412 (4), 660–673.
Web access at ScienceDirect

2010

2

G. Ilc, G. Giachin, M. Jaremko, L. Jaremko, F. Benetti, J. Plavec, I. Zhukov and G. Legname
NMR Structure of the Human Prion Protein with the Pathological Q212P Mutation Reveals Unique Structural Features
PLoS ONE 2010, 5(7): e11715. doi:10.1371/journal.pone.0011715

2008

1

D. Babic, M. Curic, K. Molcanov, G. Ilc and J. Plavec
Synthesis and Characterization of Dicylopalladated Complexes of Azobenzene Derivatives by Experimental and Computational Methods
Inorg. Chem. 2008, 47 (22), 10446-10454.