barbara mohar

Barbara Mohar

Ph.D.

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barbara.mohar@ki.si

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(01) 47-60-250

Barbara Mohar, organic chemist, received her PhD in chemistry from the University of Ljubljana in 1997, working in the group of Dr. Jože Kobe at the National Institute of Chemistry (Ljubljana). Between 1998-2000 she occupied postdoctoral positions on asymmetric synthesis projects funded by Rhodia Chimie (France) in Prof. Charles Mioskowski's group at the University of Louis Pasteur (Strasbourg, France) and in Prof. Jean-Christoph Plaquevent at IRCOF-University of Rouen (France).
Further on, from 2000-2010 she was head of the Laboratory for Organic & Medicinal Chemistry at the National Institute of Chemistry (Slovenia). After joining the National Centre for NMR Spectroscopy in January 2011, she holds a research position in the group of Prof. Dr. Janez Plavec.
Since her postdoc, her research focus has been in the area of catalysis, synthesis of ligands/catalysts and their application in asymmetric catalysis of industrially relevant molecules.

Access to my Scientific Publications and Patents.

Research Interests:

• Advanced Organic Synthesis
• Medicinal Chemistry
• Specialty Materials for Industry

2016

37

A. Emanuel Cotman, D. Cahard, and B. Mohar
Stereoarrayed CF3-Substituted 1,3-Diols by Dynamic Kinetic Resolution: Ruthenium(II)-Catalyzed Asymmetric Transfer Hydrogenation
Angew. Chem. Int. Ed. 2016, 55 (17), 5294–5298.
Web access at Willy Online Library

36

S. Rast, B. Modec, M. Stephan, B. Mohar
γ-Sultam-cored N,N-ligands in the ruthenium(II)-catalyzed asymmetric transfer hydrogenation of aryl ketones
Org. Biomol. Chem. 2016, 14, 2112-2120.
Web access at RSC Publishing

2015

35

A. Kisic, M. Stephan, and B. Mohar
ansa-Ruthenium(II) Complexes of R2NSO2DPEN-(CH2)n(η6-Aryl) Conjugate Ligands for Asymmetric Transfer Hydrogenation of Aryl Ketones
Adv. Synth. Catal. 2015, 357 (11), 2540–2546.
Web access at Willy Online Library

34

S. Rast, M. Stephan and B. Mohar
Olefin Hydrogenation with Rigid Mono-P-stereogenic Diphosphines: A Flexible Rhodium Ring to Rule Them All?
Eur. J. Org. Chem. 2015 (10), 2214–2225.
Web access at Willy Online Library.

33

J. Borisek, M. Vizovisek, P. Sosnowski, B. Turk, D. Turk, B. Mohar, and M. Novic
Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors
J. Med. Chem. 2015, 58 (17), 6928–6937.
Web access at ACS publications

2014

32

A. Kisic, M. Stephan, and B. Mohar
ansa-Ruthenium(II) Complexes of DPEN-SO2N(Me)(CH2)n6-aryl) Conjugate Ligands for Asymmetric Transfer Hydrogenation of Aryl Ketones
Adv. Synth. Catal. 2014, 356 (14/15), 3193–3198.
Web access at Wiley Online Library

31

S. Rast, B. Mohar, and M. Stephan
Efficient Asymmetric Syntheses of 1-Phenyl-phosphindane, Derivatives, and 2- or 3-Oxa Analogues: Mission Accomplished
Org. Lett. 2014, 16 (10), 2688–2691.
Web access at ACS publications

2013

30

B. Mohar and M. Stephan
Practical Enantioselective Hydrogenation of α-Aryl- and α-Carboxyamidoethylenes by Rhodium(I)-{1,2-Bis[(o-tert-butoxyphenyl)(phenyl)phosphino]ethane}
Adv. Synth. Catal. 2013, 356 (2/3), 594–600.
Web access at Willy Online Library

29

B. Mohar, A. Cusak, B. Modec, and M. Stephan
P-Stereogenic Phospholanes or Phosphorinanes from o-Biarylylphosphines: Two Bridges not too far
J. Org. Chem. 2013, 78 (10), 4665–4673.
Web access at ACS publications

28

A. Kisic, M. Stephan, and B. Mohar
Asymmetric Transfer Hydrogenation of 1-Naphthyl Ketones by an ansa-Ru(II) Complex of a DPEN-SO2N(Me)-(CH2)26-p-Tol) Combined Ligand
Org. Lett., 2013, 15 (7), 1614–1617.
Web access at ACS publications

2012

27

S. Rast, M. Stephan, and B. Mohar
Synthesis and use of ortho-(branched alkoxy)-tert-butoxybenzenes
Tetrahedron Lett. 2012, 53 (50), 6815–6818.
Web access at ScienecDirect

2011

26

M. Stephan, D. Sterk, B. Zupancic, and B. Mohar
Profiling the tuneable R-SMS-Phos structure in the rhodium(I)-catalyzed hydrogenation of olefins: the last stand?
Org. Biomol. Chem. 2011, 9 (14), 5266–5271.
Web access at RSC Publishing

24

M. Stephan, B. Zupancic, and B. Mohar
Synthesis of bulky 1,2-dialkoxy- and 1,2,3-trialkoxy-arenes
Tetrahedron 2011, 67 (34), 6308–6315.
Web access at ScienecDirect

2010

23

B. Zupancic, M. Stephan, and B. Mohar
Heavyweight "R-SMS-Phos" ligands in the olefins' hydrogenation arena
Org. Lett. 2010, 12 (6), 1296–1299.
Web access at ACS publications

22

B. Zupancic, B. Mohar, and M. Stephan
Impact on Hydrogenation Catalytic Cycle of the R Groups' Cyclic Feature in "R-SMS-Phos"
Org. Lett. 2010, 12 (13), 3022–3025.
Web access at ACS publications

21

B. Mohar, M. Stephan, and U. Urleb
Stereoselective synthesis of fluorine-containing analogues of anti-bacterial sanfetrinem and LK-157
Tetrahedron 2010, 66, 4144–4149.
Web access at ScienecDirect

2009

20

M. Stephan, D. Sterk, and B. Mohar
DiPAMPs big brother "i-Pr-SMS-Phos" exhibits exceptional features enhancing rhodium(I)-catalyzed hydrogenation of olefins
Adv. Synth. Catal. 2009, 351 (17), 2779–2786.
Web access at Willy Online Library

19

I. Plantan, M. Stephan, U. Urleb, and B. Mohar
Stereoselective synthesis of (1'S,3R,4R)-4-acetoxy-3-(2'-fluoro-1'-trimethylsilyloxyethyl)-2-azetidinone
Tetrahedron Lett. 2009, 50 (22), 2676–2677.
Web access at ScienecDirect

18

B. Zupancic, B. Mohar, and M. Stephan
Study of incidence of DiPAMP ligand modification on the rhodium(I)-catalyzed asymmetric hydrogenation of -acetamidostyrene
Tetrahedron Lett. 2009, 50 (52), 7382–7384.
Web access at ScienecDirect

2008

17

B. Zupancic, B. Mohar, and M.l Stephan
Impact of incorporating substituents onto the P-o-anisyl groups of DiPAMP ligand on the rhodium(I)-catalyzed asymmetric hydrogenation of olefins
Adv. Synth. Catal. 2008, 350 (13), 2024–2032.
Web access at Willy Online Library

2007

16

M. Stephan, D. Sterk, B. Modec, and B. Mohar
Study of the reaction of bulky aryllithium reagents with 3,4-dimethyl-2, 5-diphenyl-1,3,2-oxazaphospholidine-2-borane derived from ephedrine
J. Org. Chem. 2007, 72 (21), 8010–8018.
Web access at ACS publications

2006

15

D. Sterk, M. Stephan, and B. Mohar
Highly enantioselective transfer hydrogenation of fluoroalkyl ketones
Org. Lett. 2006, 8 (26), 5935–5938.
Web access at ACS publications

14

M. Stephan and B. Mohar
Simple preparation of highly pure monomeric ω-hydroxycarboxylic acids
Org. Process Res. Dev. 2006, 10 (3), 481–483.
Web access at ACS publications

2005

13

M. Zorko, A. Majerle, D. Sarlah, M. Mancek Keber, B. Mohar, R. Jerala
Combination of antimicrobial and endotoxin neutralizing activity of novel oleoylamines
Antimicrobial Agents & Chemotherapy 2005, 49, 2307–2313.

12

B. Mohar, D. Sterk, L. Ferron, and D. Cahard
DEnantioselective and diastereoselective synthesis of fluorinated dipeptides by late electrophilic fluorination
Tetrahedron Lett. 2005, 46 (30), 5029–5031.
Web access at ScienecDirect

2004

11

D. Sterk, M. Stephan, and B. Mohar
Transfer hydrogenation of activated ketones using novel chiral Ru(II)-N-arenesulfonyl-1, 2-diphenylethylenediamine complexes
Tetrahedron Lett. 2004, 45 (3), 535–537.
Web access at ScienecDirect

2002

10

F. Taran, C. Gauchet, B. Mohar, S. Meunier, A. Valleix, P. Yves Renard, C. Créminon, J. Grassi, A. Wagner, C. Mioskowski
High-throughput screening of enantioselective catalysts by immunoassay
Angew. Chem. Int. Ed. 2002, 41 (1), 124–127.

9

D. Sterk, M. Stephan, and B. Mohar
New chiral N-(N,N-dialkylamino)sulfamoyl-1,2-diamine ligands for highly enantioselective transfer hydrogenation of ketones
Tetrahedron: Asymmetry 2002, 13 (23), 2505–2608.
Web access at ScienecDirect

2001

8

B. Mohar, J. Baudoux, J. Plaquevent, D. Cahard
Electrophilic fluorination mediated by Cinchona alkaloids: highly enantioselective synthesis of α-fluoro-α-phenylglycine derivatives
Angew. Chem. Int. Ed. 2001, 40 (22), 4214–4216.

7

B. Mohar, A. Valleix, J. Desmurs, M. Felemez, A. Wagner, C. Mioskowski
Highly enantioselective synthesis via dynamic kinetic resolution under transfer hydrogenation using Ru(η6-arene)-N-perfluorosulfonyl-1,2-diamine catalysts: a first insight into the relationship of the ligand's pKa and the catalyst activity
Chem. Commun. 2001, 24, 2572–2573.

1999

6

B. Mohar and J. Kobe
Chiral synthons for carba-β-D-ribonucleosides. Synthesis of carba-4-deoxypurazofurin and isomeric carba-4-deaza-oxoformycin analogues
Nucleosides & Nucleotides 1999, 18 (3), 443–465.

1998

5

M. Polak, B. Mohar, J. Kobe, J. Plavec
Anomeric effect in purine nucleosides. Evaluation of the steric effect of a purinic aglycone from the pseudorotational equilibrium of cyclopentane in carbocyclic C-nucleoside 1
J. Am. Chem. Soc. 1998, 120, 2508–2513.

1997

4

B. Mohar and J. Kobe
The synthesis of enantiomerically pure pyrazolo /4,3-c/pyridine carbaribo C-nucleoside
Nucleosides & Nucleotides 1997, 16 (7/9), 1427–1429.

3

B. Mohar, J. Kobe, G. Koomen
Approach to carbocyclic 4-deoxypyrazofurin through asymmetrisation of a meso-norbornene derivative
Synlett 1997, 12, 1467–1468.

1994

2

B. Mohar, A. Stimac, and J. Kobe
Chiral building blocks of carbocyclic N- and C-ribonucleosides through biocatalytic asymmetrisation of meso-cyclopentane-1,3-dimethanols
Tetrahedron: Asymmetry 1994, 5 (5), 863–878.

1993

1

B. Mohar, A. Stimac, and J. Kobe
Enantioselective synthesis of the carbocyclic tetrazole C-ribonucleosides
Nucleosides & Nucleotides 1993, 12 (8), 793–802.

10

A. Štimac, B. Mohar, M. Stephan, et al.
Process for the preparation of “ezetimibe” and derivatives
US2013190487; EA2012017349; WO2008089984; CN101679236

9

A. Cusak, E. Jeretin, B. Mohar, M. Stephan
Nove P-kiralne fosforjeve spojine, njihovi katalizatorji in uporaba v enantioselektivni katalizi
SI2013/23833

8

B. Mohar, R. Zupet, M. Stephan, et al.
Preparation of “duloxetine” and its pharmaceutically acceptable salts by the use of asymmetric hydrogenation process
WO2010/003942

7

A. Avdagic, B. Mohar, D. Sterk, M. Stephan.
Novel form of a benzenesulfonamide derivative
WO2006008562, US20117868174; CA2574362

6

U. Urleb, B. Mohar, M. Stephan, et al
New trinem antibiotics and inhibitors of β
US2011166118; RU2011101493; JP2011524879; WO2009153297; EP2307415

5

B. Mohar, R. Toplak Casar
Process for the preparation of enantiomerically enriched proton pump inhibitors
US 2012046319; WO2010043601

4

R. Lenarčič, R. Zupet, B. Mohar et al.
Process and intermediates for the preparation of olanzapine
US2009/7498433

3

M. Stephan, B. Mohar
New ortho-functionalized P-chiral arylphosphines and derivatives: their preparation and use in asymmetric catalysis
US 2010/099875; WO2006136695

2

M. Stephan, B. Mohar
Preparation of highly pure monomeric 6-hydroxycaproic acid and other ω-hydroxycarboxylic acids
FR2006/2871798

1

A. Wagner, C. Mioskowski, B. Mohar, J. Desmurs, F. le Guyader, T. Schlama
Sulfonylamides and carboxamides and their use in asymmetric catalysis
FR2003/2800371