UPCOMING EVENTS
LATEST NEWS
The lab of Prof. Dr. Katrin Paeschke (www.paeschkelab.de) is looking for a highly motivated and determined candidate for a PhD position.
Find more information here
14. 2. 2020
CERIC, Central European Research Infrastructure Consortium, offers access to more than 50 instruments and two support laboratories, for multidisciplinary research in all fields of materials, biomaterials and nanotechnology. Researchers from all over the world can apply for access free of charge, upon the condition that results are published and CERIC acknowledged. CERIC also offers support for mobility of two users per proposal, and awards for high-quality open access publications.
There are two deadlines:
- March 2nd, 17hs CET, to have a pre-evaluation and the possibility to improve your proposal.
- March 31st, 17hs CET, recommended only for expert users of all the techniques requested.
Find more information here
30. 1. 2020
A new paper reports on the first high-resolution structure of a G-quadruplex bis-quinolinium ligand 360A intercalating into a G-rich tetrahelical fold. G-rich oligonucleotide VK2 folds into an AGCGA-quadruplex tetrahelical structure distinct and significantly different from G-quadruplexes, even though it contains four G3 tracts. 360A is shown to strongly bind to VK2 athough it is known for its high affinity for G-quadruplex structures and selective telomerase inhibition. Upon binding, 360A does not induce a conformational switch from VK2 to an expected G-quadruplex, but forms a well-defined 1:1 complex. 360A intercalates between GAGA- and GCGC-quartets in the central cavity of VK2.
For more information read the original paper: here